Adverse reactions are similar in terms of nature, severity, and frequency to those reported previously with amlodipine and atorvastatin.Common side effects are fatigue, flatulence (gas), heartburn, and constipation.Doses greater than 20 mg have not been studied in this patient population.With ultracentrifugation, these complexes separate into HDL (high-density lipoprotein), IDL (intermediate-density lipoprotein), LDL (low-density lipoprotein), and VLDL (very-low-density lipoprotein) fractions.Atherosclerosis is a chronic process, and discontinuation of lipid-lowering drugs during pregnancy should have little impact on long-term outcomes of primary hypercholesterolemia therapy.
LAB-0276-31.0 PATIENT INFORMATION ( CAD -oo-et) Read the patient information that comes with CADUET before you start taking it, and each time you get a refill.The effect of amlodipine on the pharmacokinetics of atorvastatin showed no effect on the Cmax: 91% (90% confidence interval: 80 to 103%), but the AUC of atorvastatin increased by 18% (90% confidence interval: 109 to 127%) in the presence of amlodipine, which is not clinically meaningful.Co-administered amlodipine does not affect the exposure to atorvastatin, digoxin, ethanol and the warfarin prothrombin response time.Atorvastatin also reduces VLDL-C and TG and produces variable increases in HDL-C and apolipoprotein A-1.
CADUET: Following oral administration of CADUET, peak plasma concentrations of amlodipine and atorvastatin are seen at 6 to 12 hours and 1 to 2 hours post dosing, respectively.Atorvastatin Calcium Analysis Samples: Sample solution and Blank Instrumental conditions.
No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older adults cannot be ruled out.You have high blood pressure when the force of blood against the walls of your arteries stays high.Liver Enzymes: Advise patients treated with CADUET to report promptly any symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice.Upon dose reduction, drug interruption, or discontinuation, transaminase levels returned to or near pretreatment levels without sequelae.Atorvastatin 7.9-fold increase 2.3-fold increase Amlodipine.Cmax and AUC are each 4-fold greater in patients with Childs-Pugh A disease.Muscle Pain: Advise patients starting therapy with CADUET of the risk of myopathy and to report promptly any unexplained muscle pain, tenderness, or weakness particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after discontinuing CADUET.Pregnancy: Women of childbearing age should be advised to use an effective method of birth control to prevent pregnancy while using CADUET.
Study shows both cholesterol-lowering drugs are equally safe and effective.
Absolute bioavailability has been estimated to be between 64% and 90%.Amlodipine may be used as monotherapy or in combination with other antianginal agents.
Information for Patients Because of the risk of myopathy with statins, the drug class to which atorvastatin belongs, advise patients to report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.In clinical trials with angina patients alone, amlodipine therapy did not alter electrocardiographic intervals or produce higher degrees of AV blocks.There are a number of atorvastatin side effects that patients should be aware of.A Pharmacoepidemiology Study of the Interaction Between Atorvastatin and Clopidogrel After Percutaneous Coronary Intervention.We do offer support to patients taking Teva medicines, although we are really limited to what we can say here on our website.The starting dose and maintenance doses of atorvastatin should be individualized according to patient characteristics such as goal of therapy and response (see current NCEP Guidelines ).Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.
Find patient medical information for Atorvastatin oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Amlodipine should be used during pregnancy only if the potential benefit justifies the risk to the fetus.